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. 2016 Apr 13;17(4):553. doi: 10.3390/ijms17040553

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© 2016 by the authors; licensee MDPI, Basel, Switzerland.

This article is an open access article distributed under the terms and conditions of the Creative Commons by Attribution (CC-BY) license (http://creativecommons.org/licenses/by/4.0/).

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Model of hematopoietic differentiation within a Hematopoietic Unit (HU). Mesenchymal stromal cells (MSCs) are key components of HU; they contact hematopoietic stem cells (HSC) and their progeny as well as the other components of the stem cell niche. Differentiation occurs according to the topobiology of the progenitors, Erythroid (Ery), Megakaryocytic (Meg), Myeloid (My), Lymphoid (Ly) and Monocytic (Mono). MSCs may act as scaffolds that help progenitors to localize in particular regions and to direct their contact with other microenvironmental cells.