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. 2016 Apr 13;17(4):553. doi: 10.3390/ijms17040553

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© 2016 by the authors; licensee MDPI, Basel, Switzerland.

This article is an open access article distributed under the terms and conditions of the Creative Commons by Attribution (CC-BY) license (http://creativecommons.org/licenses/by/4.0/).

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Topobiology of a Myelodysplastic Syndrome (MDS) Hematopoietic Unit (HU). In MDS patients there is a decrease in osteoblasts (accompanied by decreased CXCL12 in paratrabecular areas) and an increase and redistribution of MSC density such that the parenchyma is traversed by a dense MSC meshwork that aberrantly expresses CXCL12. The change in the distribution and secretion pattern of MSCs leads to a re-location of CD34+ hematopoietic progenitor stem/ cells (HPSCs) to the parenchyma, where they are in the proximity of increased iron overloaded macrophages (mQs) overexpressing heme oxygenase-1 (HO1).