. 2016 Apr 19;17(4):572. doi: 10.3390/ijms17040572

Table 1.

Associations of single nucleotide polymorphisms in genes encoding sirtuins (SIRTs) with obesity and related complications.

Gene	Polymorphism	Allele/Genotype	Association	Population	References
SIRT1	rs2273773 (T/C)	C	Lower intima-media thickness in men	1770 Austrian Caucasians	[98]
		C	Higher intima-media thickness in women	1770 Austrian Caucasians	[98]
		C	Higher TC and LDL-C levels in male hemodialysis patients	219 Japanese hemodialysis patients, 803 control subjects	[106]
		T	Associated with cardiovascular diseases	278 Turkish patients with CVD 135 controls	[103]
		CT	Higher BMI compared to TT homozygotes	3575 Dutch Caucasians	[90]
		CT	Higher insulin levels	120 obese Turkish children 120 lean controls	[95]
		CC	Higher systolic and diastolic blood pressure in men	1279 Japanese	[94]
		TT	Higher fat content and higher fasting glucose in men	1279 Japanese	[94]
		TT	Higher diastolic blood pressure and higher TC and LDL-C levels	70 Egyptian	[107]
		No association with obesity and susceptibility to lifestyle modification		196 German Caucasians	[93]
		No influence on mortality and on glucose tolerance in obese individuals		1390 Dutch Caucasians	[96]
	rs7069102 (G/C)	G	Associated with CVD	278 Turkish patients with CVD 135 controls	[103]
		CC	Lower risk of obesity but higher visceral fat Content in men	1068 obese subjects, 313 lean controls (Belgian Caucasians)	[91]
		GG	Higher fat content and higher systolic blood pressure in men	1279 Japanese	[94]
		No association with obesity		896 obese subjects, 532 lean controls (French Caucasians) 154 Swedish families (732 subjects) 120 obese Turkish children and 120 lean controls	[77,95]
		No association with obesity and susceptibility to lifestyle modification		196 German Caucasians	[93]
		No influence on mortality and on glucose tolerance in obese individuals		1390 Dutch Caucasians	[96]
	rs7895833 (A/G)	G	Lower BMI	8598 Dutch Caucasians	[92]
	rs7895833 (A/G)	G	Higher BMI	120 obese Turkish children 120 lean controls	[95]
	rs7895833 (A/G)	A	Increased mortality in diabetic patients (in a haplotype with rs1467568G/ rs497849G)	8598 Dutch Caucasians	[92]
		AA	higher BMI and higher fat content in men	1279 Japanese	[94]
		AA	higher diastolic blood pressure in women	1279 Japanese	[94]
		AG	Higher BMI	120 obese Turkish children 120 lean controls	[95]
		GG	Higher diastolic blood pressure and higher TC and LDL-C levels	70 Egyptians	[107]
		No association with BMI and fat content		3501 Pima Indians 3003 Native Americans	[79]
	rs1467568 (A/G)	G	lower BMI	8598 Dutch Caucasians	[92]
		G	Increased mortality in diabetic patients (in a haplotype with rs7895833A/rs497849G)	8598 Dutch Caucasians	[92]
		G	Lower intima-media thickness in men	1770 Austrian Caucasians	[98]
		G	Higher intima-media thickness in women	1770 Austrian Caucasians	[98]
		No association with obesity		896 obese subjects, 532 lean controls (French Caucasians) 154 Swedish families (732 subjects)	[77]
	rs12413112 (G/A)	A	Higher BMI	896 obese subjects, 532 lean controls (French Caucasians) 154 Swedish families (732 subjects)	[77]
		A	Lower energy expenditure and resistance to lifestyle interventions	196 German Caucasians	[93]
		A	Higher mean common intima-media thickness	1770 Austrian Caucasians	[98]
		No association with BMI and weight		1279 Japanese	[94]
	rs33957861 (C/T)	T	Higher BMI	896 obese subjects, 532 lean controls (French Caucasians) 154 Swedish families (732 subjects)	[77]
	rs11599176 (A/G)	G	Higher BMI	896 obese subjects, 532 lean controls (French Caucasians) 154 Swedish families (732 subjects)	[77]
	rs35689145 (G/A)	A	Higher BMI	896 obese subjects, 532 lean controls (French Caucasians) 154 Swedish families (732 subjects)	[77]
	rs730821 (A/G)	No association with BMI and weight		1279 Japanese	[94]
	rs12778366 (C/T)	C	Reduced mortality in obese/overweight individuals	1390 Dutch Caucasians	[96]
	rs12778366 (C/T)	C	Better glucose tolerance in men	1390 Dutch Caucasians	[96]
	rs12049646 (C/T)	T	Higher BMI in men	1802 Spanish Caucasians	[97]
	rs3740051 (A/G)	G	Lower intima-media thickness in men	1770 Austrian Caucasians	[98]
	rs3740051 (A/G)	G	Higher intima-media thickness in women	1770 Austrian Caucasians	[98]
	rs2236319 (A/G)	G	Lower intima-media thickness in men	1770 Austrian Caucasians	[98]
		G	Higher intima-media thickness in women	1770 Austrian Caucasians	[98]
		A	Associated with diabetic nephropathy	1502 Japanese patients with T2DM 1740 controls	[105]
	rs10823108 (G/A)	A	Lower intima-media thickness in men	1770 Austrian Caucasians	[98]
		A	Higher intima-media thickness in women	1770 Austrian Caucasians	[98]
		G	Associated with diabetic nephropathy	1502 Japanese patients with T2DM 1740 controls	[105]
	rs4746720 (T/C)	T	Associated with diabetic nephropathy	1502 Japanese patients with T2DM 1740 controls	[105]
	rs4746720 (T/C)	No association with BMI and fat content		3501 Pima Indians 3003 Native Americans	[79]
	rs497849 (G/A)	G	Increased mortality in diabetic patients (in a haplotype with rs1467568G/rs7895833A)	8598 Dutch Caucasians	[92]
	rs10509291 (T/A)	T	Associated with type 2 diabetes	3501 Pima Indians	[79]
		T	Not associated with type 2 diabetes	3003 Native Americans	[79]
		No association with BMI and fat content		6504 North Americans	[79]
	rs7896005 (G/A)	G	Associated with type 2 diabetes	3501 Pima Indians	[79]
	rs7896005 (G/A)	G	Not associated with type 2 diabetes	3003 Native Americans	[79]
	–	No association with BMI and fat content		6504 North Americans	[79]
	rs3758391 (C/T)	C	Protects from type 2 diabetes	519 Mexican patients with T2DM 389 Mexican patients with MS 547 Mexican controls	[104]
	rs3818292 (A/G)	A	Associated with diabetic nephropathy	1502 Japanese patients with T2DM 1740 controls	[105]
SIRT2	rs4802998 (A/G)	G	Higher intima-media thickness	1356 North Americans	[100]
SIRT3	rs12363280 (C/G)	G	Higher grey scale median indicator of plaque morphology and a predictor of stroke	1356 North Americans	[99]
	rs12363280 (C/G)	C	Lower intima media thickness	1356 North Americans	[100]
	rs4980329 (T/C)	T	Higher grey scale median—an indicator of plaque morphology and a predictor of stroke	1356 North Americans	[99]
	rs3825075 (T/C)	TT	Lower intima media thickness in women	1356 North Americans	[100]
SIRT5	rs4712032 (A/G)	G	Increased number of carotid plaques	1356 North Americans	[99]
SIRT5	rs12216101 (G /T)	G	Increased number of carotid plaques	1356 North Americans	[99]
SIRT6	rs107251 (C/T)	T	Increased number of carotid plaques	1356 North Americans	[99,101]
SIRT6	rs3760905 (G/T)	T	Increased number of carotid plaques	1356 North Americans	[99,101]

BMI—Body mass index; CVD—cardiovascular diseases; LDL-C—low density lipoproteins cholesterol; MS—Metabolic syndrome; T2DM—Type 2 diabetes mellitus; TC—Total cholesterol.