Table 1.
Gene | Polymorphism | Allele/Genotype | Association | Population | References |
---|---|---|---|---|---|
SIRT1 | rs2273773 (T/C) | C | Lower intima-media thickness in men | 1770 Austrian Caucasians | [98] |
C | Higher intima-media thickness in women | 1770 Austrian Caucasians | [98] | ||
C | Higher TC and LDL-C levels in male hemodialysis patients | 219 Japanese hemodialysis patients, 803 control subjects | [106] | ||
T | Associated with cardiovascular diseases | 278 Turkish patients with CVD 135 controls |
[103] | ||
CT | Higher BMI compared to TT homozygotes | 3575 Dutch Caucasians | [90] | ||
CT | Higher insulin levels | 120 obese Turkish children 120 lean controls |
[95] | ||
CC | Higher systolic and diastolic blood pressure in men | 1279 Japanese | [94] | ||
TT | Higher fat content and higher fasting glucose in men | 1279 Japanese | [94] | ||
TT | Higher diastolic blood pressure and higher TC and LDL-C levels | 70 Egyptian | [107] | ||
No association with obesity and susceptibility to lifestyle modification | 196 German Caucasians | [93] | |||
No influence on mortality and on glucose tolerance in obese individuals | 1390 Dutch Caucasians | [96] | |||
rs7069102 (G/C) | G | Associated with CVD | 278 Turkish patients with CVD 135 controls |
[103] | |
CC | Lower risk of obesity but higher visceral fat Content in men | 1068 obese subjects, 313 lean controls (Belgian Caucasians) | [91] | ||
GG | Higher fat content and higher systolic blood pressure in men | 1279 Japanese | [94] | ||
No association with obesity | 896 obese subjects, 532 lean controls (French Caucasians) 154 Swedish families (732 subjects) 120 obese Turkish children and 120 lean controls | [77,95] | |||
No association with obesity and susceptibility to lifestyle modification | 196 German Caucasians | [93] | |||
No influence on mortality and on glucose tolerance in obese individuals | 1390 Dutch Caucasians | [96] | |||
rs7895833 (A/G) | G | Lower BMI | 8598 Dutch Caucasians | [92] | |
G | Higher BMI | 120 obese Turkish children 120 lean controls |
[95] | ||
rs7895833 (A/G) | A | Increased mortality in diabetic patients (in a haplotype with rs1467568G/ rs497849G) | 8598 Dutch Caucasians | [92] | |
AA | higher BMI and higher fat content in men | 1279 Japanese | [94] | ||
AA | higher diastolic blood pressure in women | 1279 Japanese | [94] | ||
AG | Higher BMI | 120 obese Turkish children 120 lean controls |
[95] | ||
GG | Higher diastolic blood pressure and higher TC and LDL-C levels | 70 Egyptians | [107] | ||
No association with BMI and fat content | 3501 Pima Indians 3003 Native Americans |
[79] | |||
rs1467568 (A/G) | G | lower BMI | 8598 Dutch Caucasians | [92] | |
G | Increased mortality in diabetic patients (in a haplotype with rs7895833A/rs497849G) | 8598 Dutch Caucasians | [92] | ||
G | Lower intima-media thickness in men | 1770 Austrian Caucasians | [98] | ||
G | Higher intima-media thickness in women | 1770 Austrian Caucasians | [98] | ||
No association with obesity | 896 obese subjects, 532 lean controls (French Caucasians) 154 Swedish families (732 subjects) |
[77] | |||
rs12413112 (G/A) | A | Higher BMI | 896 obese subjects, 532 lean controls (French Caucasians) 154 Swedish families (732 subjects) |
[77] | |
A | Lower energy expenditure and resistance to lifestyle interventions | 196 German Caucasians | [93] | ||
A | Higher mean common intima-media thickness | 1770 Austrian Caucasians | [98] | ||
No association with BMI and weight | 1279 Japanese | [94] | |||
rs33957861 (C/T) | T | Higher BMI | 896 obese subjects, 532 lean controls (French Caucasians) 154 Swedish families (732 subjects) |
[77] | |
rs11599176 (A/G) | G | Higher BMI | 896 obese subjects, 532 lean controls (French Caucasians) 154 Swedish families (732 subjects) |
[77] | |
rs35689145 (G/A) | A | Higher BMI | 896 obese subjects, 532 lean controls (French Caucasians) 154 Swedish families (732 subjects) |
[77] | |
rs730821 (A/G) | No association with BMI and weight | 1279 Japanese | [94] | ||
rs12778366 (C/T) | C | Reduced mortality in obese/overweight individuals | 1390 Dutch Caucasians | [96] | |
C | Better glucose tolerance in men | 1390 Dutch Caucasians | [96] | ||
rs12049646 (C/T) | T | Higher BMI in men | 1802 Spanish Caucasians | [97] | |
rs3740051 (A/G) | G | Lower intima-media thickness in men | 1770 Austrian Caucasians | [98] | |
G | Higher intima-media thickness in women | 1770 Austrian Caucasians | [98] | ||
rs2236319 (A/G) | G | Lower intima-media thickness in men | 1770 Austrian Caucasians | [98] | |
G | Higher intima-media thickness in women | 1770 Austrian Caucasians | [98] | ||
A | Associated with diabetic nephropathy | 1502 Japanese patients with T2DM 1740 controls |
[105] | ||
rs10823108 (G/A) | A | Lower intima-media thickness in men | 1770 Austrian Caucasians | [98] | |
A | Higher intima-media thickness in women | 1770 Austrian Caucasians | [98] | ||
G | Associated with diabetic nephropathy | 1502 Japanese patients with T2DM 1740 controls |
[105] | ||
rs4746720 (T/C) | T | Associated with diabetic nephropathy | 1502 Japanese patients with T2DM 1740 controls |
[105] | |
No association with BMI and fat content | 3501 Pima Indians 3003 Native Americans |
[79] | |||
rs497849 (G/A) | G | Increased mortality in diabetic patients (in a haplotype with rs1467568G/rs7895833A) | 8598 Dutch Caucasians | [92] | |
rs10509291 (T/A) | T | Associated with type 2 diabetes | 3501 Pima Indians | [79] | |
T | Not associated with type 2 diabetes | 3003 Native Americans | [79] | ||
No association with BMI and fat content | 6504 North Americans | [79] | |||
rs7896005 (G/A) | G | Associated with type 2 diabetes | 3501 Pima Indians | [79] | |
G | Not associated with type 2 diabetes | 3003 Native Americans | [79] | ||
– | No association with BMI and fat content | 6504 North Americans | [79] | ||
rs3758391 (C/T) | C | Protects from type 2 diabetes | 519 Mexican patients with T2DM 389 Mexican patients with MS 547 Mexican controls |
[104] | |
rs3818292 (A/G) | A | Associated with diabetic nephropathy | 1502 Japanese patients with T2DM 1740 controls |
[105] | |
SIRT2 | rs4802998 (A/G) | G | Higher intima-media thickness | 1356 North Americans | [100] |
SIRT3 | rs12363280 (C/G) | G | Higher grey scale median indicator of plaque morphology and a predictor of stroke | 1356 North Americans | [99] |
C | Lower intima media thickness | 1356 North Americans | [100] | ||
rs4980329 (T/C) | T | Higher grey scale median—an indicator of plaque morphology and a predictor of stroke | 1356 North Americans | [99] | |
rs3825075 (T/C) | TT | Lower intima media thickness in women | 1356 North Americans | [100] | |
SIRT5 | rs4712032 (A/G) | G | Increased number of carotid plaques | 1356 North Americans | [99] |
rs12216101 (G /T) | G | Increased number of carotid plaques | 1356 North Americans | [99] | |
SIRT6 | rs107251 (C/T) | T | Increased number of carotid plaques | 1356 North Americans | [99,101] |
rs3760905 (G/T) | T | Increased number of carotid plaques | 1356 North Americans | [99,101] |
BMI—Body mass index; CVD—cardiovascular diseases; LDL-C—low density lipoproteins cholesterol; MS—Metabolic syndrome; T2DM—Type 2 diabetes mellitus; TC—Total cholesterol.