2D	two-dimensional
3D	three-dimensional
300 µM BR	300 µM bioreactors
1000 µM BR	1000 µM bioreactors
A1AT	α-1-antitrypsin
ABCB1	ATP-binding cassette B1
ABCC2	ATP-binding cassette C2
ABCG2	ATP-binding cassette G2
ALB	albumin
ALT	alanine transaminase
ARG1	arginase 1
APOC1	apolipoprotein C-I
ASL	argininosuccinate lyase
AST	aspartate transaminase
ATF3	activating transcription factor 3
B2M	β -2-microglobulin
BCRP	breast cancer resistance protein
CK 18	cytokeratin 18
control BR	control bioreactors
CPS1	mitochondrial carbamoyl-phosphate synthase 1
CYP	cytochrome P450
DILI	drug-induced liver injury
DMSO	dimethyl sulfoxide
FDR	False Discovery Rate
GLDH	glutamate dehydrogenase
GDF15	growth differentiation factor 15
LDH	lactate dehydrogenase
MS	mass spectrometry
NRF2/KEAP1	nuclear factor (erythroid-derived 2)-like 2/kelch-like ECH-associated protein 1
OTC	ornithine transcarbamoylase
pHH	primary human hepatocytes
SEM	standard errors of the mean
TTR	transthyretin
UDP	uridine diphosphate
UGT2B7	UDP glucuronosyltransferase 2B7