Table 2.
Genotypic and allelic frequencies of the rs1333040, rs1333042, rs4977574, rs2066715 and rs2740483 SNPs in controls and patients (n (%)).
| SNP/Group | Genotype | Allele | pHWE | ||||
|---|---|---|---|---|---|---|---|
| N | AA | AB | BB | A | B | ||
| rs1333040 (C>T) | |||||||
| Control | 541 | 60 (11.1) | 225 (41.6) | 256 (47.3) | 345 (31.9) | 737 (68.1) | 0.322 |
| CHD | 565 | 39 (6.9) | 232 (41.1) | 294 (52.0) | 310 (27.4) | 820 (72.6) | 0.457 |
| IS | 569 | 55 (9.7) | 247 (43.4) | 267 (46.9) | 357 (31.4) | 781 (68.6) | 0.846 |
| pCHD | 0.035 | 0.022 | |||||
| pIS | 0.681 | 0.794 | |||||
| rs1333042 (A>G) | |||||||
| Control | 541 | 67 (12.4) | 219 (40.5) | 227 (42.0) | 353 (32.6) | 729 (67.4) | 0.941 |
| CHD | 565 | 43 (7.60) | 227 (40.2) | 255 (59.2) | 313 (27.7) | 817 (72.3) | 0.065 |
| IS | 569 | 56 (9.7) | 243 (42.7) | 270 (47.6) | 355 (31.2) | 783 (68.8) | 0.066 |
| pCHD | 0.021 | 0.011 | |||||
| pIS | 0.376 | 0.470 | |||||
| rs4977574 (A>G) | |||||||
| Control | 541 | 152 (28.1) | 255 (47.1) | 134 (24.8) | 559 (51.7) | 523 (48.3) | 0.191 |
| CHD | 565 | 117 (20.7) | 272 (48.1) | 176 (31.2) | 506 (44.8) | 624 (55.2) | 0.527 |
| IS | 569 | 121 (21.3) | 276 (48.5) | 172 (30.2) | 518 (45.5) | 620 (54.5) | 0.599 |
| pCHD | 0.006 | 0.001 | |||||
| pIS | 0.015 | 0.004 | |||||
| rs2066715 (A>G) | |||||||
| Control | 541 | 97 (17.9) | 266 (49.2) | 178 (32.9) | 460 (42.5) | 622 (57.5) | 0.891 |
| CHD | 565 | 101 (17.9) | 298 (52.7) | 166 (29.4) | 500 (44.2) | 630 (55.8) | 0.101 |
| IS | 569 | 116 (20.4) | 279 (49.0) | 174 (30.6) | 627 (55.1) | 511 (44.9) | 0.823 |
| pCHD | 0.408 | 0.411 | |||||
| pIS | 0.510 | 0.256 | |||||
| rs2740483 (C>G) | |||||||
| Control | 541 | 31 (5.70) | 183 (33.8) | 327 (60.4) | 245 (22.6) | 837 (77.4) | 0.423 |
| CHD | 565 | 17 (2.8) | 175 (31.0) | 373 (66.2) | 209 (18.5) | 921 (81.5) | 0.516 |
| IS | 569 | 9 (1.6) | 152 (26.7) | 408 (71.7) | 170 (14.9) | 969 (85.1) | 0.223 |
| pCHD | 0.034 | 0.016 | |||||
| pIS | 0.000 | 0.000 | |||||
SNP, single nucleotide polymorphism; CHD, coronary heart disease; IS, ischemic stroke; HWE, Hardy-Weinberg equilibrium; AA, rs1333040CC, rs1333042AA, rs4977574AA, rs2066715AA, and rs2740483CC genotypes; AB, rs1333040CT, rs1333042AG, rs4977574AG, rs2066715AG, and rs2740483CG genotypes; BB, rs1333040TT, rs1333042GG, rs4977574GG, rs2066715GG, and rs2740483GG genotypes; A, rs1333040C, rs1333042A, rs4977574A, rs2066715A, and rs2740483C alleles; and B, rs1333040T, rs1333042G, rs4977574G, rs2066715G, and rs2740483G alleles. pHWE, the p value of the Handy-Weinberg equilibrium.