. Author manuscript; available in PMC: 2016 Jun 1.

Published in final edited form as: Arch Dis Child Fetal Neonatal Ed. 2015 Nov 13;101(3):F201–F206. doi: 10.1136/archdischild-2015-308899

Table 2.

Outcomes at 18 – 22 months for infants based on receipt of anti-hypotensive therapy & rise in blood pressure

	Untreated expected BP rise (n=91)	Untreated less than expected BP rise (n=67)	Treated expected BP rise (n=128)	Treated less than expected BP rise (n=70)	p-value
Death or any ND impairment/delay, # (%)	24 (26)	19 (28)	58 (45)	33 (47)	0.002
^*Any ND impairment/delay, # (%)	9 (14)	6 (12)	16 (23)	14 (30)	0.079
Language composite score, mean ± SD	86 ± 16	87 ± 13	84 ± 17	83 ± 18	0.531
Cognitive composite score, mean ± SD	91 ± 14	90 ± 10	86 ± 17	88 ± 17	0.33
Motor composite score, mean ± SD	89 ± 15	89 ± 12	86 ± 17	86 ± 18	0.53
^*Language composite score < 70, # (%)	8 (12)	2 (4)	13 (19)	9 (19)	0.081
^*Cognitive composite score <70, # (%)	5 (8)	1 (2)	11 (16)	7 (15)	0.0554
^*Motor composite score <70, # (%)	7 (11)	4 (8)	10 (14)	10 (21)	0.162
^*GMFCS level ≥2, # (%)	4(6)	4(8)	9 (13)	8 (17)	0.251
^*Blindness, # (%)	1 (2)	0	0	0	0.697^¶
^*Deafness, # (%)	1 (2)	1 (2)	1 (1)	3 (6)	0.426^¶

BP = blood pressure; ANOVA = analysis of variance; ND = neurodevelopment; SD = standard deviation; GMFCS = Gross Motor Function Classification System;

denominator is infants who had a neurodevelopmental assessment at 18 – 22 months corrected age

^¶

Fisher's Exact Test