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. 2016 Feb 11;7(2):e2094. doi: 10.1038/cddis.2016.11

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Copyright © 2016 Macmillan Publishers Limited

Cell Death and Disease is an open-access journal published by Nature Publishing Group. This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article's Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/

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Synergistic treatment with PL and ZA suppresses RANKL-induced activation of the NF-κB/MAPK pathways. After starvation treatment containing various drugs, RANKL was added for 20 min to activate osteoclastogenesis-related signaling pathways. (Aa) The suppressive effects on the NF-κB signaling cascade. (b) Protein expression levels of NF-κB were calculated. (Ba) The repressive effects on the MAPK signaling pathway. (b) Protein expression levels of MAPK were calculated. The data are presented as the means±S.D. All experiments were repeated at least three times (**significant difference at P<0.05)