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. 2016 Feb 11;7(2):e2094. doi: 10.1038/cddis.2016.11

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Copyright © 2016 Macmillan Publishers Limited

Cell Death and Disease is an open-access journal published by Nature Publishing Group. This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article's Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/

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Combined treatment with PL and ZA synergistically inhibits the growth of MDA-MB-231SArfp cells in tumor-bearing mice. Tumor-bearing nude mice were treated with vehicle, PL (4 mg/kg), ZA (100 μg/kg) and Syn (4 mg/kg PL plus 100 μg/kg ZA) for 6 weeks. (A) Weekly noninvasive IVIS monitoring of MDA-MB-231SArfp cells inoculated in nude mice (Ba) The fluorescence intensity of tumor cells within the bone microenvironment at different time points. (b) Breast cancer tumor volume in nude mice at different time points. (c) The correlation between tumor fluorescence intensity and tumor volume. The data are presented as the means±S.D. Each group contained 10 animals (**significant difference at P<0.05)