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. 2016 Feb 11;7(2):e2094. doi: 10.1038/cddis.2016.11

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Copyright © 2016 Macmillan Publishers Limited

Cell Death and Disease is an open-access journal published by Nature Publishing Group. This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article's Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/

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Combined treatment with PL and ZA synergistically inhibits breast cancer-induced osteolysis in vivo. Representative X-ray radiographs (A), μCT tomography of whole tibiae (B) and tibial trabecular cancellous structures (C) in tumor-bearing mice after 6 weeks of treatment. (D) Quantitative data from μCT scanning revealing trabecular BV/TV (a) and Cor. BV/TV (b) after treatments with PL, ZA or both. The data are presented as the means±S.D. Each group contained 10 animals. Scale bar=1.0 mm (*significant difference at P<0.1; **significant difference at P<0.05)