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. 2016 Feb 25;7(2):e2119. doi: 10.1038/cddis.2016.32

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Copyright © 2016 Macmillan Publishers Limited

Cell Death and Disease is an open-access journal published by Nature Publishing Group. This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article's Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/

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p38 MAPK signaling regulates DKK-1 in osteolytic and osteoblastic prostate cancer cells. PC3 (a), MDA-PCa-2b (b) and DU 145 cells (c) were treated with anisomycin (2 h post culture medium change for 1 h), anisomycin in combination with either LY2228820 or SB202190 (anisomycin after 2 h post culture medium change for 1 h and LY and SB for 3 h immediately post culture medium change) and each selected inhibitor individually (for 3 h). DKK-1 mRNA expression and both total and phosphorylated protein levels of p38 MAPK and HSP27 were assessed after 3 h by western blot. All mRNA expression data of N=3 are shown as a percentage of the control untreated group and results are shown as the mean±S.D. (***P<0.001)