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. 2016 Apr 15;193(8):898–909. doi: 10.1164/rccm.201502-0407OC

Figure 1.

Figure 1.

Control (Ctrl) recipient mice transplanted with mutant (Mut) bone marrow (BM) cells developed elevated right ventricular systolic pressure (RVSP), whereas Mut mice transplanted with control BM cells had lower RVSP. (A) Experimental design. (B) Lethally irradiated Ctrl mice developed elevated RVSP when transplanted with Mut BM cells (n = 12) compared with the Ctrl group of lethally irradiated Ctrl mice transplanted with Ctrl BM cells (n = 5) (compare the first and second boxplots). Lethally irradiated Mut mice transplanted with Ctrl BM cells showed moderation of RVSP (n = 7) compared with the Ctrl group of lethally irradiated Mut mice transplanted with Mut BM cells (n = 9) (compare the third and fourth boxplots). RVSP was measured 16 weeks after transplantation. Data are shown as box-and-whisker plots, with whiskers indicating Tukey whiskers. An α level of 0.05 was chosen, and P values less than 0.05 were considered statistically significant. All P values were two-tailed. Analyses were performed with Prism 5 for Mac OS X (GraphPad Software Inc., La Jolla, CA).