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Focus on IL15 and IL18 environment during the implantation window. In the mid‐luteal phase, stromal and endothelial endometrial cells secrete IL‐15, Fn‐14, IL‐18, and TWEAK at specific levels. Increased IL‐15 allows the recruitment and maturation of uNK cells. IL‐18 and mature uNK cells stimulate Th2 cytokine production and lead to a predominantly Th2 balance. This equilibrium promotes immunotrophism and angiogenesis, while inhibiting inflammatory and cytotoxic pathways.
