Table 1.
Comparison of Endometrial Biomarkers in Control and RIF Subgroups According to Their Immune Profiles
| Immune endometrial profile | Control group | RIF group | ||||||
|---|---|---|---|---|---|---|---|---|
| Normal | Over activation | P value (anova) | Low activation | P value (anova) | Nodysregulation | P value (anova) | ||
| Biomarkers | Number of patient | 26 | 223 (56.6%) | 99 (25%) | 72 (18.3%) | |||
| IL‐18/TWEAK | Range of interpretation | 0.03–0.12 | >0.12 | <0.03 | 0.03–0.12 | |||
| Mean | 0.076 | 0.40* | 0.046 | 0.045** | 0.002 | 0.07 | 0.33 | |
| IL‐15/Fn‐14 | Range of interpretation | 0.3–3 | >3 | <0.3 | 0.3–3 | |||
| Mean | 1.2 | 2.96* | 0.039 | 0.47*** | <0.001 | 1.27 | 0.75 | |
| CD56+ cells count | Range of interpretation | 10–100 | >100 | <10 | 10–100 | |||
| Mean | 45 | 49 | 0.64 | 32** | 0.009 | 42 | 0.46 | |
Norms for each biomarker were determined from a cohort of 26 fertile women. Data for each RIF subgroup were compared to data for the control group and analyzed with anova. A p‐value <0.05 was considered statistically significant.
* = P < 0.05, ** = P < 0.01, *** = P < 0.001.