Skip to main content
. 2016 Jan 13;47(2):253–257. doi: 10.1111/age.12410

Figure 1.

Figure 1

Genetics of cholesterol deficiency (CD) in Holstein cattle. (a) Pedigree of selected partially inbred Holstein cattle. The two BTA 11 haplotypes are indicated beneath each animal's name. Black symbols represent the ancestral haplotype; those labeled CD indicate the mutant ancestral haplotype. The bull Maughlin Storm (red arrow) is the possible founder animal for CD. Thus, the mutation (indicated by CD) must have occurred either in the germlines of Fairlea Royal Mark, Wykholme Dewdrop Gail or Wykholme Dewdrop Tacy or during the early embryonic development of Maughlin Storm. Gray symbols represent any other wild‐type haplotype of this region of BTA 11. Due to the inbreeding loop through ancestor Fairlea Royal Mark, the male Dudoc Mr Burns has inherited two versions of the ancestral haplotype. His maternal copy of the ancestral haplotype carries the CD mutation, whereas his paternal copy is still in its ancestral wild‐type state. (b) High‐density SNP marker‐based homozygosity mapping across the genome of two affected calves. Extended segments of shared homozygosity are shown in blue. Note should be taken that the largest homozygous segment is located on BTA 11. The observed recombination event (red arrow) in the non‐affected carrier male Dudoc Mr Burns allowed the determination of a 2.24‐Mb critical interval (indicated in red) containing the APOB gene.