Table 1.

Hepcidin agonists.

Mechanism of action	Drug	Target	Evidence	Clinical stage	Ref.	Implicated disorders
Hepcidin mimetics	Minihepcidins	FPN	Cell culture and animal models	Preclinical	[79–81]	Hereditary hemochromatosis; iron loading anemias
	LJPC-401	FPN	Animal models	Preclinical	[82,83]
Enhance positive regulators	BMP6 administration	BMP pathway	Cell culture and animal models	Preclinical	[84]
Inhibit negative regulators	ALN-TMP	TMPRSS6 inhibitor	Cell culture and animal models	Preclinical	[85]