Figure 2.

NTSp colonizes the chinchilla middle ear and induces otitis media. Chinchillas were inoculated via transbullar injection with a high- or low-dose S. pneumoniae strain MNZ1113. At three and seven days post-inoculation, pneumococcal bacterial loads were quantitated in homogenized middle ear bullae (A) and middle ear fluid (B). The dashed line indicates the bacterial limit of detection.