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. 2016 Apr 13;3:16006. doi: 10.1038/mto.2016.6

Figure 2.

Figure 2

Immunosuppressive tumor microenvironment. This diagram represents a simplified schema of the negative elements that barrage activated chimeric antigen receptor T cells as they navigate through the tumor landscape, thereby inactivating them. These barriers in solid tumors rapidly neutralize the antitumor effect.