Table 3. Fractional anisotropy for tracts connecting subregions of the striatum with the frontal cortex regions.

	HC (n=58)	SB (n=30)	SZ (n=24)	P (HC versus SB)	P (HC versus SZ)	P (SB versus SZ)
Nucleus accumbens–DLPFC
R	0.38±0.02	0.37±0.02	0.37±0.02	0.16	0.22	0.92
L	0.35±0.01	0.34±0.02	0.33±0.02	0.0008*	0.0003*	0.58
Nucleus accumbens–mOFC
R	0.22±0.01	0.21±0.01	0.22±0.01	0.24	0.63	0.55
L	0.21±0.01	0.21±0.02	0.21±0.01	0.82	0.80	0.72
Nucleus accumbens–IFG
R	0.27±0.01	0.27±0.02	0.27±0.01	0.42	0.48	0.94
L	0.25±0.01	0.25±0.01	0.26±0.01	0.92	0.10	0.16
Caudate–DLPFC
R	0.37±0.02	0.37±0.02	0.37±0.02	0.86	0.23	0.38
L	0.36±0.02	0.35±0.02	0.36±0.03	0.57	0.17	0.09
Caudate–mOFC
R	0.29±0.02	0.29±0.01	0.29±0.02	0.70	0.92	0.80
L	0.28±0.02	0.28±0.01	0.29±0.02	0.92	0.48	0.55
Caudate–IFG
R	0.35±0.01	0.35±0.02	0.35±0.01	0.78	0.19	0.20
L	0.33±0.01	0.33±0.02	0.33±0.01	0.72	0.95	0.72
Putamen–DLPFC
R	0.39±0.02	0.39±0.02	0.39±0.02	0.89	0.75	0.86
L	0.38±0.02	0.38±0.02	0.39±0.02	0.55	0.27	0.11
Putamen–mOFC
R	0.32±0.02	0.32±0.02	0.31±0.01	0.67	0.74	0.50
L	0.28±0.02	0.28±0.01	0.28±0.01	0.41	0.91	0.51
Putamen–IFG
R	0.26±0.01	0.25±0.01	0.25±0.01	0.72	0.33	0.50
L	0.24±0.01	0.24±0.01	0.24±0.01	0.45	0.84	0.37

Abbreviations: DLPFC, dorsolateral prefrontal cortex; HC, healthy controls; IFG, inferior frontal gyrus; L, left; mOFC, medial orbital frontal cortex; R, right; SB, unaffected siblings of schizophrenia patients; SZ, schizophrenia patients.

P values with * survived Bonferroni correction for multiple testing. Values represent mean±s.d.