Table 2.
Odds ratio for the association of house dust endotoxin – serum vitamin D interaction with asthma and wheeze outcomes
| Endotoxin / Vitamin D |
|
|||||||
|---|---|---|---|---|---|---|---|---|
| Association of endotoxin with asthma and wheeze outcomes
|
Interactions
|
|||||||
| Low / Normal | Low / Low | High / Normal | High / Low | Multiplicative | RERI (95% CI) | AP (95% CI) | S (95% CI) | |
|
| ||||||||
| OR (95% CI) | OR (95% CI) | OR (95% CI) | OR (95% CI) | |||||
|
|
|
|
|
|
|
|||
| Asthma Outcomes | ||||||||
| Asthma Diagnosis | 1 (reference) | 1.21 (0.89, 1.64) | 1.07 (0.74, 1.55) | 1.53 (1.20, 1.94)** | 1.19 (0.79, 1.79) | 0.25 (−0.22, 0.71) | 0.16 (−0.14, 0.46) | 1.86 (0.38, 9.04) |
| Past Asthma | 1 (reference) | 1.16 (0.70, 1.90) | 1.03 (0.64, 1.65) | 1.47 (1.00, 2.17)* | 1.23 (0.80, 1.90) | 0.29 (−0.16, 0.74) | 0.20 (−0.09, 0.48) | 2.59 (0.24, 28.05) |
| Current Asthma | 1 (reference) | 1.23 (0.75, 2.01) | 1.06 (0.60, 1.88) | 1.56 (1.09, 2.23)* | 1.23 (0.60, 2.51) | 0.28 (−0.48, 1.00) | 0.18 (−0.31, 0.66) | 1.97 (0.11, 36.49) |
| Wheeze Outcomes | ||||||||
| Any Wheeze | 1 (reference) | 1.41 (0.90, 2.20) | 1.10 (0.62, 1.94) | 1.72 (1.10, 3.71)* | 1.12 (0.66, 1.92) | 0.22 (−0.26, 0.69) | 0.13 (−0.18, 0.43) | 1.42 (0.42, 4.82) |
| ≥ 2 wheezing episodes | 1 (reference) | 1.48 (0.72, 3.04) | 1.19 (0.49, 2.88) | 1.97 (1.00, 4.00)* | 1.12 (0.47, 2.67) | 0.30 (−0.70, 1.46) | 0.15 (−0.36, 1.35) | 1.45 (0.14, 96.98) |
| Combined outcomes | ||||||||
| Asthma diagnosis or recurrent wheeze | 1 (reference) | 1.44 (0.92, 2.24) | 1.30 (0.94, 1.79) | 1.88 (1.33, 2.66)** | 1.01 (0.66, 1.53) | 0.14 (−0.26, 0.54) | 0.08 (−0.14, 0.28) | 1.20 (0.62, 6.43) |
| Current asthma Or recurrent wheeze | 1 (reference) | 1.39 (0.83, 2.32) | 1.22 (0.73, 2.03) | 1.81 (1.23, 2.68)** | 1.07 (0.61, 1.86) | 0.20 (−0.40, 0.88) | 0.11 (−0.21, 0.49) | 1.33 (0.35, 15.96) |
AP, attributable proportion due to interaction; BMI, body mass index; RERI, relative excess risk due to interaction; S, synergy index;
Models adjusted for age, PIR, MET (used as continuous variables), gender, race/ethnicity, number of people in the household, presence of a smoker in the household, BMI, number of years lived in the house, presence of mildew, cockroaches, and pets in the home, pets avoidance because of allergies, as well as sensitization to aeroallergens (used as categorical variables). RERI and AP are significant when the 95% CI do not include 0.0. SI is significant when the 95% CI do not include 1.0.