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(a) A schematic for patient selection. (b) An example of serum rapamycin level before, during and after a diarrheal episode in a single patient. Plots showing each serum rapamycin level in 20 patients with 39 episodes of profound diarrhea (c) and each serum tacrolimus level in 12 patients (d) at baseline, during and after the diarrheal episodes. * indicates p<0.001 (comparison between during and pre- or post-diarrheal episode) (one-way ANOVA with a Bonferroni test).
