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. Author manuscript; available in PMC: 2017 Jun 14.
Published in final edited form as: Neuroscience. 2016 Mar 26;325:142–152. doi: 10.1016/j.neuroscience.2016.03.049

Fig. 3.

Fig. 3

Prior isoflurane anesthesia and preconditioning effects. A) PIDs under anesthesia. Propagated hyperemic CBF transients monitored by perfusion imaging during 4 hours under isoflurane anesthesia were markedly attenuated when MCA occlusion occurred 1 day after a previous anesthesia exposure, and this effect persisted in some animals at 1 week. Open circles, anesthesia accompanied by sham surgery; circled dots, anesthesia only; shaded bar, mean ± SD for the Naïve group. * P ≤ 0.05 vs. Naïve and ≥ 2week groups. B) PIDs in awake animals. PIDs were recorded from electrode arrays placed at the indicated intervals prior to MCA occlusion, with subsequent monitoring for up to 3 days. PID incidence was reduced at 1 day and 1 week relative to longer recovery intervals after electrode placement. Shaded bars, mean ± SD for historical results obtained from naïve animals under anesthesia with α-chloralose (Zhao and Nowak, 2015), or isoflurane (from panel A). * P ≤ 0.05 for pooled 1 day and 1 week groups vs. ≥ 2 week group.