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. 2016 Apr 28;11(4):e0152911. doi: 10.1371/journal.pone.0152911

Fig 5. Impact of LVAD support level on infarct size in a dog model of ischemia reperfusion.

Fig 5

(A): Representative left ventricular (LV) sections after staining with Evan’s blue and TTC. The area at risk (red) and the infarct area (white) were traced and measured by using an image analyzer. (B): Quantification of risk area in LV. There are no difference among three groups. (C): Assessment of infarct ratio (infarct area/risk area, %). Compared to control (no LVAD support, n = 6), p-LVAD (n = 5) moderately lowers the infarct ratio (p = 0.011), while t-LVAD (n = 5) strikingly decreases the infarct ratio by more than 80% (p<0.01). (D): Changes in serum creatine kinase-MB (CK-MB) 300 min after reperfusion in the three groups. (B-D): Data are expressed as means ± SD. *p < 0.05 versus Control; †p < 0.01 versus Control; ‡p<0.01 versus p-LVAD.