Table 2. Impact of level of left ventricular assist device (LVAD) support on hemodynamics in a dog model of ischemia-reperfusion.
| HR | MAP | CO | LVAD flow | RAP | LAP | Peak LVP | |
|---|---|---|---|---|---|---|---|
| (bpm) | (mmHg) | (ml/min/kg) | (ml/min/kg) | (mmHg) | (mmHg) | (mmHg) | |
| Baseline | |||||||
| Control | 149±7 | 101±18 | 96±13 | 0 | 3.0±1.3 | 5.7±1.5 | − |
| p-LVAD | 144±17 | 96±11 | 92±10 | 0 | 3.0±0.7 | 5.3±0.8 | − |
| t-LVAD | 141±7 | 94±13 | 103±13 | 0 | 3.5±1.1 | 6.0±0.9 | − |
| 90 min after ischemia | |||||||
| Control | 132±18 | 98±19 | 106±23 | 0 | 4.2±1.9 | 9.9±2.9 | − |
| p-LVAD | 139±20 | 114±18 | 63±16* | 65±18* | 3.2±1.2 | 5.0±3.0* | − |
| t-LVAD | 147±4 | 115±13 | 0*† | 125±24*† | 3.3±0.8 | 0.9±0.3*† | 32±2 |
| 300 min after reperfusion | |||||||
| Control | 111±13 | 97±18 | 68±13 | 0 | 4.4±1.7 | 11.5±4.8 | − |
| p-LVAD | 117±11 | 99±12 | 26±4* | 28±4* | 3.0±2.0 | 7.9±4.5* | − |
| t-LVAD | 124±11* | 104±20 | 0*† | 62±16*† | 4.0±0.6 | 0.5±0.3*† | 28±7 |
Data are expressed as means ± SD. Control, no LVAD support (n = 6); p-LVAD, partial LVAD support (n = 5); t-LVAD, total LVAD support (n = 5); HR, heart rate; MAP, mean arterial pressure; CO, cardiac output; LVAD flow, flow of left ventricular assist device; RAP, right atrial pressure; LAP, left atrial pressure; Peak LVP, peak LV pressure.
*p < 0.05 versus Control;
†p < 0.05 versus p-LVAD.