Table 1. Susceptibility to miltefosine (MIL) of the different L. infantum strains.
Strain | Intracellular amastigotes IC50 (mean ± SEM) | Promastigotes IC50 (mean ± SEM) |
---|---|---|
LEM3323 | 2.3 ± 0.5 | 5.3 ± 0.3 |
LEM3323-MIL | >20.0 | >40.0 |
LEM3323-MIL + LiMT | 3.0 ± 1.0 | 2.4 ± 1.2 |
LEM3049 | 0.8 ± 0.4 | 5.6 ± 1.1 |
LEM5159 | > 20.0 | > 40.0 |
LEM5159 + LiRos3 | 0.5 ± 0.3 | 3.8 ± 1.3 |
LEM5159 + LiMT | > 20.0 | > 40.0 |
ΔLdMT | > 20.0 | > 40.0 |
ΔLdMT + LiMTGFP | 3.5 ± 2.3 | 12.8 ± 0.8 |
ΔLdMT + LiMTE926QGFP | 4.3 ± 1.6 | 16.1 ± 0.8 |
Li: L. infantum; Ld: L. donovani