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. 2016 Apr 28;12(4):e1004884. doi: 10.1371/journal.pcbi.1004884

Fig 7. Expression of polarized genes in laser-capture micro-dissected tumour and normal tissue.

Fig 7

The differential expression patterns of polarised genes linked to CNV and Gleason score in the Tomlins et al LCM-based gene expression dataset. 36/58 genes were mapped from the network (see Fig 5) to the independent dataset. (A) Expression of all but 1 of the polarised differentially expressed in the LCM dataset (11/36) was downregulated in low and high-grade tumour tissue compared to healthy prostate. (B-D) Expression of several polarised genes linked to CNV and Gleason score in specific prostate tumour compartments isolated by the Tomlins et al study. Nor = normal prostate tissue, BPH = benign prostate hyperplasia, Adj = prostate tissue adjacent to tumour, PIN = intraepithelial neoplasia, PCA-L = low-grade tumour, PCA-H = high-grade tumour, Meta = metastatic tumour tissue. * p < 0.05, ** p < 0.01 *** p < 0.001.