Table 5. Prediction performance of individual molecular type under LLR, as measured by AUC.
| Unbalanced | Balanced | |||
|---|---|---|---|---|
| Type of Variable | mean AUC | Std | mean AUC | Std |
| Age | 0.8034 | 0.0150 | 0.8070 | 0.0901 |
| Germline Mutation | 0.5169 | 0.0395 | 0.5490 | 0.0832 |
| Somatic Mutation | 0.6156 | 0.0354 | 0.6451 | 0.0724 |
| Gene Expression | 0.7385 | 0.0322 | 0.6665 | 0.0706 |
| DNA methylation | 0.8387 | 0.0341 | 0.6747 | 0.0962 |
| miRNA | 0.7350 | 0.0272 | 0.6577 | 0.0724 |
| CNV | 0.7002 | 0.0232 | 0.6785 | 0.0599 |
The last two columns are the mean and standard deviations of AUC under 100 bootstrap permutations (i.e. downsampling the ~10% of non-LTS cases and 90% of LTS so that the number of samples is equal to that in LTS).