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. 2004 Aug 1;114(3):330–338. doi: 10.1172/JCI20622

Figure 7.

Figure 7

CD34+ cell transplantation in 24-week-old animals. (A–C) On day 35 after cell transplantation, the brains were evaluated. Compared with poststroke mice treated with CD34– cells (A), animals transplanted with CD34+ cells (B) showed an increase in area occupied by the left cortex. Significant cortical regeneration was induced by CD34+ cells transplantation (C). (D and E) Compared with CD34– cell transplantation (D), increased evidence of activated vasculature was observed in animals receiving CD34+ cells (E), as detected with mouse specific anti-CD13 antibody. (F–H) Migration of NPCs (small NeuN+ nuclei migrating toward the cortex) was observed in poststroke mice treated with CD34– cells (F) and with CD34+ cells (G). However, a significant increase in migrating NPCs was induced by CD34+ cell transplantation (H). (I and J) A thin layer of migrating PSA-NCAM+ NPCs was observed at the ischemic edge of the cortex in animals treated with CD34– cells (I), compared with a much thicker layer in those receiving CD34+ cells (J). Scale bars: 2 mm (A), 0.1 mm (D and I), and 0.4 mm (F). n = 4 in each group; *P < 0.05 versus CD34– cells.