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. 2004 Aug 1;114(3):322–329. doi: 10.1172/JCI21153

Figure 6.

Figure 6

Administration of recombinant IFN-γ results in obstruction of extrahepatic bile ducts in IFN-γ–/– mice. H&E staining of transverse sections along the extrahepatic bile duct of an IFN-γ–/– mouse that received daily intraperitoneal injections of 2,000 U of recombinant IFN-γ per gram body weight following RRV challenge. (A) A patent proximal segment of the duct. (B) A narrow lumen with increasing periductal inflammation (approximately 700 μm from the section in A). (C) Section approximately 100 μm from the section in B; the inflammation completely occludes the extrahepatic bile duct. Magnification ×200.