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Persistent infiltration of portal space by neutrophils in IFN-γ–/– mice. RRV challenge induces a neutrophil-based pericholangitis within 3 days in WT and IFN-γ–/– mice (A and B). In WT mice, inflammatory cells switch to lymphocytes in expanded portal spaces 7–14 days after challenge (C and E). This switch is incomplete in IFN-γ–/– mice, which continue to display portal neutrophils (D and F). Arrows point to neutrophils.
