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. 2015 Sep 15;27(5):1321–1333. doi: 10.1681/ASN.2014090906

Figure 1.

Figure 1.

MC presence and activation status in renal biopsies from patients with MPO-AAV. Frequency of kidney MCs was determined by immunohistochemical staining for MC tryptase (A and B). Prominent interstitial MC accumulation was observed in patients with MPO-AAV (n=44 patients biopsies) compared with patients with minimal change GN (n=9 patient biopsies) (C). Patients with severe tubulointerstitial injury had greater numbers of infiltrating MCs (D). Most MCs in MPO-AAV biopsies (n=25) were degranulated (E and F; intact MC, black arrow and degranulated MC, red arrow) and spindle shaped (G and H; green arrow). Error bars represent mean±SEM with statistical analysis by Mann–Whitney t-test. ***P<0.001, **P<0.01.