Table 1.

Urine parameters for urea transporter–deficient mice

	Control		UT-A1+/+/UT-A3−/−		UT-A1−/−/UT-A3−/−
	Hydrated	Dehydrated	Hydrated	Dehydrated	Hydrated	Dehydrated
24-hour volume (ml)	1.7±0.2	0.65±0.1	1.8±0.2	0.6±0.1	5.0±0.6	2.1±0.4
Urine urea (mmol/L)	1543±52	2229±209	1286±64	1968±188	799±124	1037±164
Urea excretion/24-hour (mmoles)	2.6±0.3	1.3±0.1a	2.3±0.2	1.1±0.2a	3.6±0.4	1.9±0.1a
Urea excretion (mmol/day/100 g body wt)	8.9±1.0	5.2±0.5a	7.6±0.7	4.2±0.7a	11.6±1.2b	6.7±0.3a

Values are mean±SEM, n=8 mice per genotype per condition.

^aSignificantly different from hydrated of the same genotype, P<0.05.

^bSignificantly different from hydrated WT, P<0.05.