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Treatment of diabetic mice with INT-777 increases mediators of renal mitochondrial biogenesis. Representative QPCR or Western blot results show that the treatment with INT-777 induces significant increases in (A) phospho-AMPK and AMPK protein, (B) phospho-ACC protein, (C) SIRT1 mRNA and protein, (D) PGC-1α protein, (E) ERRα mRNA and protein, (F) SIRT3 mRNA, (G) Nrf1 mRNA, and SIRT3 activity as shown by the decreased acetylation of SIRT3 targets (H) SOD2 and (I) IDH2.
