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. 2015 Sep 30;27(5):1362–1378. doi: 10.1681/ASN.2014121271

Figure 3.

Figure 3.

Treatment of diabetic mice with INT-777 decreases oxidative stress. (A) Mitochondrial ROS generation is increased in mitochondria isolated from db/db mice and treatment with INT-777 decreased mitochondrial ROS generation. (B) Total SOD activity is decreased in the kidneys of db/db mice and treatment with INT-777 increases total SOD activity. (C) Mitochondrial SOD activity is decreased in mitochondria isolated from db/db mice and treatment with INT-777 increases mitochondrial SOD activity. (D) Urinary TBARS excretion, a marker of oxidative stress, is increased in db/db mice and treatment with INT-777 decreases urinary TBARS excretion. (E) Urinary H2O2 excretion, a marker of oxidative stress, is increased in db/db mice and treatment with INT-777 decreases urinary H2O2 excretion.