Table 2.
Pathologic findings in LCPT
| Number (%) | |
|---|---|
| Total no. of participants | 46 |
| Crystalline | 40c |
| Noncrystalline | 6 |
| κ LC | 43/45 (96)d |
| Detection by IF-frozen | 15/43 (35) |
| Detection by IF-pronase | 37/38 (97) |
| ATI scorea | |
| Absent | 4 |
| Mild/patchy | 6 |
| Severe/diffuse | 36 |
| Interstitial fibrosis/tubular atrophy scoreb | |
| 0 | 11 |
| 1 | 17 |
| 2 | 15 |
| 3 | 3 |
| Interstitial inflammationb | |
| 0 | 13 |
| 1 | 28 |
| 2 | 5 |
| 3 | 0 |
| Tubular casts | |
| Absent | 37 |
| Focal | 9 |
LC, light chain.
a
0=absent, 1=mild, 2=moderate, 3=severe.
b
Scores: 0 (absent), 1 (<25% of cortical area), 2 (25%–49% of cortical area), and 3 (≥50% of cortical area).
c
Five patients showed crystals by EM only.
d
One case that did not stain for κ or λ light chain by IF performed on both frozen and pronase-digested paraffin tissue was known to have monoclonal κ light chain in urine.