Table 3.
Clinical and demographic characteristics of LCPT
| Characteristic | All Patients (n=46) | Crystalline (n=40) | Noncrystalline (n=6) |
|---|---|---|---|
| Age, yra | 62.5 (60) | 61.4 (59) | 74.5 (72) |
| (Range) | (39–87) | (39–87) | (61–87) |
| Male (%) | 63 | 68 | 33 |
| White (%) | 85 | 83 | 100 |
| Serum monoclonal spike | 32/45 (71%) | 27/39 (69%) | 5/6 (83%) |
| Urine monoclonal spike | 31/33 (94%) | 29/30 (97%) | 2/3 (66%) |
| Positive FLC | 10/11 (91%) | 8/9 (89%) | 2/2 (100%) |
| Hematologic diagnoses | |||
| MM | 15 | 10 | 5 |
| Smoldering myeloma | 7 | 6 | 1 |
| MGRS | 21 | 21 | 0 |
| Other diagnosesb | 3 | 3 | 0 |
| FS | 17/43 (40%) | 17/38 (43.4%) | 0/5 (0%) |
| SCr, mg/dla | 2.38 (2.0) | 2.4 (2.1) | 2.4 (1.0) |
| eGFR by CKD-EPI, ml/min per 1.73 m2a | 38.3 (36.4) | 35.3 (34.6) | 53.8 (60.5) |
| eGFR<60, ml/min per 1.73 m2 | 38/46 (83%) | 35/40 (88%) | 3/6 (50%) |
| AKI | 10/46 (22%) | 8/40 (20%) | 2/6 (33%) |
| Proteinuria, g/24 ha | 3.07 (2.51) | 2.97 (2.45) | 4.4 (4.2) |
| <1 | 6 | 4 | 2 |
| 1–3 | 23 | 23 | 0 |
| >3 | 17 | 13 | 4 |
| Serum albumin, g/dlc | 4.0±0.1 | 4.0±0.1 | 4.1±0.2 |
CKD-EPI, Chronic Kidney Disease Epidemiology Collaboration 2009 formula28; FLC, free light chain assay; SCr, serum creatinine.
a
Values are mean (median).
b
Other diagnoses: non-Hodgkin lymphoma (n=2) and chronic lymphocytic leukemia (n=1).
c
Mean±SEM.