Table 2.
Immune phenotype of study participants at enrolment
| Variable | RTRSCC | RTRNo | P Value |
|---|---|---|---|
| Lymphocyte count | 1135 (863–1658) | 1360 (1040–1728) | 0.15 |
| Monocyte count | 500 (410–635) | 475 (413–600) | 0.58 |
| Total (CD3+) T cell count | 945 (649–1339) | 1157 (785–1467) | 0.25 |
| Gamma-delta T cell count | 33 (14–79) | 38 (13–97) | 0.77 |
| Gamma-delta T cell percentage | 2.6 (1.5–5.5) | 3.0 (1.2–6.7) | 0.83 |
| CD4+ T cell count | 567 (431–700) | 666 (474–836) | 0.13 |
| CD4+ T cell percentage | 48 (39–61) | 49 (40–60) | 0.79 |
| Treg (CD4+CD69-CD25hiCD127loFoxP3+) cell count | 16 (9–22) | 13 (9–19) | 0.51 |
| Treg percentage (of CD4+ population) | 2.5 (1.8–3.6) | 2.3 (1.7–3.0) | 0.19 |
| CD57+ percentage (of CD4+ population) | 11 (7–28) | 11 (6–18) | 0.35 |
| CD8+ T cell count | 275 (132–410) | 284 (179–510) | 0.20 |
| CD8+ T cell percentage | 22 (15–31) | 24 (16–32) | 0.61 |
| CD8+CD57+ T cell count | 162 (48–282) | 146 (77–310) | 0.65 |
| Naïve CD8+ T cell (percentage of CD8+) | 11 (4–33) | 15 (5–34) | 0.96 |
| CD8+ TEm (percentage of CD8+) | 24 (14–39) | 22 (12–43) | 0.90 |
| CD8+ TEMRA (percentage of CD8+) | 54 (29–73) | 42 (20–74) | 0.40 |
| CD8+ TCm (percentage of CD8+) | 1 (0.4–4) | 1 (0.3–3) | 0.50 |
| CD57+ percentage (of CD8+ population) | 67 (39–76) | 53 (36–70) | 0.18 |
| >50% of CD8+ T cells CD57+ (‘CD57hi’ phenotype) | 36 (61) | 29 (50) | 0.21 |
| NK cell (CD3-CD56+) count | 30 (16–109) | 43 (13–121) | 0.97 |
| NK cell percentage | 3.5 (1.4–9.7) | 3.1 (1.0–9.1) | 0.70 |
| CD19+ B cell count | 19 (8–44) | 19 (12–40) | 0.45 |
| CD19+ B cell percentage | 1.7 (0.9–3.7) | 1.8 (0.9–2.9) | 0.38 |
Continuous variables are reported as median (IQR) while categorical variables are reported as number (percentage of column). Counts are reported as cells per microliter of blood, while percentages are reported as a fraction of the lymphocyte population, unless specified otherwise. Groups were compared by Mann–Whitney test.