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Fractional excretion of creatine and guanidinoacetate in individuals with and without the heterozygous p.Q215× MCT12 mutation. Fractional excretion of (A) creatine or (B) guanidinoacetate in individuals with (patients) and without (controls) MCT12 mutation. Fractional excretions were calculated using cystatin-C-based GFR estimates. Data are medians with interquartile range. FE, fractional excretion; NS, nonsignificant.
