Table 1.

Classification of GN

Pathogenic Type	Specific Disease Entity	Pattern of Injury: Focal or Diffuse	Scores or Class
Immune-complex GNa	IgA nephropathy, IgA vasculitis, lupus nephritis, infection-related GN, fibrillary GN with polyclonal Ig deposits	Mesangial, endocapillary, exudative, membranoproliferative, necrotizing, crescentic, sclerosing, or multipleb	Oxford/MEST scores for IgA nephropathy
			ISN/RPS class for lupus nephritis
Pauci-immune GN	MPO-ANCA GN, proteinase 3-ANCA GN, ANCA-negative GN	Necrotizing, crescentic, sclerosing, or multipleb	Focal, crescentic, mixed, or sclerosing class (Berden/EUVAS class)
Anti-GBM GN	Anti-GBM GN	Necrotizing, crescentic, sclerosing, or mixedb
Monoclonal Ig GNa	Monoclonal Ig deposition disease, proliferative GN with monoclonal Ig deposits, immunotactoid glomerulopathy, fibrillary GN with monoclonal Ig deposits	Mesangial, endocapillary, exudative, membranoproliferative, necrotizing, crescentic, sclerosing, or multipleb
C3 glomerulopathy	C3 GN, dense deposit disease	Mesangial, endocapillary, exudative, membranoproliferative, necrotizing, crescentic, sclerosing, or multipleb

MEST, mesangial hypercellularity, endocapillary hypercellularity, segmental sclerosis, interstitial fibrosis/tubular atrophy; ISN/RPS, International Society of Nephrology/Renal Pathology Society; EUVAS, European vasculitis study group.

^aSome pathologists use the terms immune complex–mediated GN, monoclonal Ig–associated GN, etc. It is up to the discretion of the pathologist to use these terms.

^bMultiple patterns include two or more patterns of injury. The patterns should be stated (e.g., focal mesangial proliferative, crescentic, and sclerosing or diffuse necrotizing, crescentic, and sclerosing).