Table 7.

Guidelines for EM

No. of glomeruli studied by EM, including no. globally sclerosed or with other evident lesions

Glomerular deposits: location, type, quantity, size, and substructure

GBM: architecture, thin/thick, duplication, ischemic changes, and rupture

Endothelium: fenestrations, swelling, and presence of tubuloreticular inclusions

Mesangial matrix: normal/increased and mesangiolysis

Mesangial cellularity: normal/increased

Podocytes: preserved or effaced (%), protein reabsorption granules, and microvillus change

Leukocytes/platelets/fibrin in capillary lumen/Bowman’s space

Tubular epithelial and basement membrane abnormalities when present