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Clinical history of the patient. A 66-yr-old Caucasian man was diagnosed with infiltrative papillary breast cancer. While on tamoxifen, he developed a contralateral infiltrative ductal breast carcinoma (pretreatment sample). Following disease progression of his metastasis, he was treated with BEZ235 and everolimus. Stable disease was maintained for 18 mo. Upon nodal metastasis, treatment was discontinued and the postprogression sample collected.
