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. Author manuscript; available in PMC: 2016 Jul 15.
Published in final edited form as: ACS Chem Neurosci. 2015 May 26;6(7):1110–1115. doi: 10.1021/acschemneuro.5b00034

Figure 1.

Figure 1

5-HT1A receptor-mediated autoinhibition in the DRN: some possible models. The DRN contains both serotonergic neurons (green) and nonserotonergic neurons (gray). (A) The traditional model proposes that serotonin autoinhibition is activity-dependent and is mediated through serotonin release from axonal collaterals (pink arrow) or dendrites (red arrow). (B) An alternative model proposes that serotonin is released secondary to local dendritic depolarizations elicited by glutamatergic synapses51,52 (blue). (C) Finally, it is possible that serotonergic autoinhibition may reflect serotonergic afferents to the DRN from caudal serotonergic cell groups54 (red arrow).