Table 1.
Summary of common genetic variants linked to IPF
| Locus | Gene | SNP | IPF Risk |
IPF Survival |
Reference |
|---|---|---|---|---|---|
| 2q14 | IL1RN | rs408392 rs419598 rs2637988 |
Y Y Y |
[31-33] | |
| 3q26 | hTR | rs6793295 | Y | [40] | |
| 4q13 | IL8 | rs4073 rs2227307 |
Y Y |
[34] | |
| 4q22 | FAM13A | rs2609255 | Y | [40] | |
| 4q35 | TLR3 | rs3775291 | Harmful | [35] | |
| 5p15 | TERT | rs2736100 | Y | [40, 112] | |
| 6p21 6p21 |
CDKN1A
HLA- DRB1 |
rs2395655 | Y | Harmful Y |
[37] [36] |
| 6q24 | DSP | rs2076295 | Y | [40] | |
| 7q22 | Intergenic | rs47274443 | Y | [40] | |
| 10q24 | OBFC1 | rs11191865 | Y | [40] | |
| 11p15 |
MUC5B
MUC2 TOLLIP TOLLIP TOLLIP |
rs35705950 rs7934606 rs111521887 rs5743894 rs2743890 |
Y Y Y Y Y |
Protective Protective |
[38-43, 50] [40] [41] [41] [41] |
| 13q34 | ATP11A | rs1278769 | Y | [40] | |
| 14q21 | MDGA2 | rs7144383 | Y | [41] | |
| 15q14- 15 |
Intergenic | rs2034650 | Y | [40] | |
| 17q13 |
TP53
TP53 |
rs12951053 rs12602273 |
N N |
Harmful Harmful |
[37] |
| 17q21 17q21 |
MAPT
SPPL2C |
rs1981997 rs17690703 |
Y Y |
[40] [41] |
|
| 19q13 19q13 |
DPP9
TGFB1 |
rs12610495 rs1800470 |
Y N |
Harmful |
[40] [29, 30] |