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. Author manuscript; available in PMC: 2016 Apr 28.
Published in final edited form as: J Neurophysiol. 2009 Aug 12;102(4):2273–2287. doi: 10.1152/jn.00282.2009

FIG. 6.

FIG. 6

The small conductance (SK) channel blocker, UCL-1684 (UCL), induces burst firing with characteristics similar to those observed under BAPTA treatment. A: representative extracellular recording under control conditions. B: extracellular recording from the same neuron after UCL treatment showing burst firing. C: ISI distributions under control (dotted) and after UCL treatment (black). D: UCL significantly increases the burst fraction. E: UCL significantly decreases the cell’s absolute refractory period. E: UCL significantly decreases the time constant. Note that the changes seen in C–F are similar to the changes seen with BAPTA (cf. with Fig. 4). G: like BAPTA, UCL causes a significant reduction in the spike-triggered average amplitude. H: like BAPTA, UCL also causes a significant reduction in the mutual information rate MI. The asterisks indicate statistical significance at the P = 0.05 level.