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. Author manuscript; available in PMC: 2017 May 1.
Published in final edited form as: Arterioscler Thromb Vasc Biol. 2016 Mar 17;36(5):846–854. doi: 10.1161/ATVBAHA.116.307308

Figure 4. NOX2 promotes GPVI/ITAM-dependent and low dose thrombin-induced platelet aggregation and secretion.

Figure 4

WT control, and NOX2−/− platelets, (3 × 108/mL) were stimulated with 0.018 U/mL thrombin, 150 nM U46619 or 0.5 µg/mL CRP. (A) Platelet aggregation and ATP secretion traces. (B) Quantification of platelet aggregation. (C) Quantification of platelet secretion. ***, ** and * represents P<0.001, P<0.01 and P<0.05, respectively as determined by Student’s t-test (n=3).