Table 1.
Dbn−/+ mice were mated to generate Dbn−/− mice, which were initially viable but died prior to weaning (P21) (X2 = 16.7, 2 degrees of freedom, p = 0.001). The number of offspring for each genotype is indicated for observed and expected numbers (parentheses) based on Mendelian ratios of 1:2:1 on embryonic day 14.5 (E14.5), the day of birth (P0-1), and the day of weaning (P21). Subsequent genotyping analysis revealed neonatal mortality within 48 hours of birth.
| Analysis of Offspring of Intercrossed Heterozygotes | ||||||
|---|---|---|---|---|---|---|
| Age | WT | Het | KO | Total | X2 | p |
| E14.5 | 5 (4.25) | 5 (8.5) | 7 (4.25) | 17 | 1.64 | NS |
| P0-1 | 11 (8.75) | 13 (17.5) | 11 (8.75) | 35 | 1.18 | NS |
| P21 | 28 (19.5) | 48 (39) | 2 (19.5) | 78 | 16.7 | 0.001 |