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. Author manuscript; available in PMC: 2017 Apr 28.
Published in final edited form as: J Med Chem. 2015 Nov 9;59(8):3609–3634. doi: 10.1021/acs.jmedchem.5b01457

Figure 2.

Figure 2

Stereographical representation of the major interactions between ADP and the ATP binding site of MK2, as taken from the PDB entry 1ny3. The adenine ring is involved in two hydrogen bonds (represented as black dotted lines) with Glu139 and Leu141. An additional hydrogen bond is found between the pyrophosphate moiety and the charged terminal group of Lys93. Amino acids of the phosphate binding region, the sugar pocket, the hinge region are shown, as well as the gatekeeper Met138.