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. Author manuscript; available in PMC: 2017 Apr 28.
Published in final edited form as: J Med Chem. 2015 Nov 9;59(8):3609–3634. doi: 10.1021/acs.jmedchem.5b01457

Table 13. Squarate derivatives from Wyeth Research.

graphic file with name nihms-735690-t0125.jpg
Compd R R1 R2 IC50a (μM)
92 H Inline graphicMe Ph 8.9
93 H Inline graphicMe Ph >100
94 H H Ph 88
95 H Me m-OH-Ph 0.38
96 H CONH2 m-OH-Ph 0.39
97 graphic file with name nihms-735690-t0128.jpg Inline graphicMe Ph 0.67
a

Expressed as the inhibition of MK2 activity toward a peptide substrate.