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. Author manuscript; available in PMC: 2017 Apr 28.
Published in final edited form as: J Med Chem. 2015 Nov 9;59(8):3609–3634. doi: 10.1021/acs.jmedchem.5b01457

Table 2. Pyrrolopyridinone derivatives from Pfizer.

graphic file with name nihms-735690-t0046.jpg
Compd R IC50a (nM) EC50b (nM)
3 H 171 19000
4 Ph 66 1400
5 2-F-Ph 126 4800
6 3-naphthyl 52 4200
7 3-quinoline 8.5 4400
a

Expressed as the inhibition of MK2 ability to phosphorylate the KKKALSRQLSVAA peptide.

b

Expressed as the ability to inhibit TNFα production in LPS-stimulated U937 cells.