Table 5. Carboline analogues from Boehringer-Ingelheim Pharmaceuticals.

Compd	R1	R1, R2	IC50a (nM)	EC50b (nM)
33	NH2		5400
34			520
35			820
36			89
37			72
38			34
39			44	1600
40			10	>5000
41			20	1400
42			5	>5000
43		H, Me	7	8900
44		H, Me	4	1670
45		H, Me	3	735
46		Me, Me	2	430
47		-(CH2)3-	2	300

^aExpressed as the inhibition of MK2 in a DELFI assay.

^bExpressed as the ability to inhibit TNFα production in LPS-stimulated THP-1 cells.